[Wiscott-Aldrich syndrome [WAS]]

Wiscott-Aldrich syndrome [WAS] is an x-linked immune-deficiency disorder associated with eczema, recurrent infections, and increased frequency of autoimmune diseases, malignancy and thrombocytopenia with small size platelet. Our case is an 11 year old from a non- related parent, who was admitted with abdominal pain [hematoma], lower extremities bleeding [ecchymosed] and vomiting. Also, he had many admition cause bleeding in different areas. Lastly, he had retinal bleeding associated with blindness from 1 year ago

[Report three cases of ataxia-tlelengiectazia]

Ataxia-telangiectasia syndrome is an autosomal recessive associated with combined immunodeficiency, progressive cerebellum ataxia, telangiectasia, ocolomotor apraxia, dysartheria and respiratory infections. In this study we reported three cases from a family with classical symptoms. Second sibling was died at 13 old years because severe respiratory infection but third and forth siblings have life. The first sibling is female and normal

prevalence of asthma, allergic rhinitis and eczema in north of Iran: the international study of asthma and allergies in childhood [ISAAC]

Asthma, allergic rhinitis and eczema as a common chronic disorder in childhood, has many epidemiologic variations in different geographic areas. Uniform and standard epidemiologic researches are able to clear and modify scientific questions in this field. We carried out this study to determine the prevalence and intensity of pediatric allergic disease in our region. This analytical-cross sectional study was performed on 2 groups of children; the first group aged 6-7 years [n=3240] and the second group aged 12-14 years [n=3254] during 2002-03. According to ISAAC programming, sample size consisted of 3000 children in each group. From all students 99.3% of primary students and 88.8% of guidance students entered into study. Data was gathered by ISAAC first phase questionnaire and analyzed by SPSS 10 and Chi square test. The 12-month prevalence rates of symptoms were as follow: wheezing 16.8% and 21.7%, allergic rhinitis symptoms 14.5% and 19.9% and atopic dermatitis symptoms 4.5% and 8.2%, for younger and older age group, respectively. The prevalence of wheezing and current wheeze did not show differences according to sex [P > 0.05] but it was significantly higher in students of guidance school [P < 0.05]. The prevalence of previous history of asthma, speech disorders, wheezing after physical exercises and dry cough at night, rhinoconjuntivitis, recurrent rhinitis, eczema with pruritus, recurrent lesions and history of eczema was significantly higher in boys and in students of guidance school [P < 0.05]. The prevalence of flexor lesion did not show a significant difference according to age [P > 0.05] but in boys it was higher than in the girls [P < 0.05]. According to our findings asthma, allergic rhinitis and eczema have a moderate prevalence in this region of our country

Effect of aerobic exercise training on pulmonary function and tolerance of activity in asthmatic patients

The aim of the present study was to examine the effects of a course of aerobic exercise on pulmonary function and tolerance of activity in asthmatic patients. Among the asthmatic patients, 36 patients [M= 16, F= 20] were chosen after clinical examinations, pulmonary function test, skin prick test [SPT] for aeroallergen and a six minute walk test [6MWT] on their own free will. A patient was said to have Exercise Induced Asthma [EIA] when he/she fulfilled the following criteria; [1] FEV[1] < 80%, [2] 12% increase or more in FEV[1] or PEF after short-acting [beta][2] agonist prescription and [3] 15% decrease in FEV[1] or PEF after 6MWT with 70% or 80% of maximum heart rate. The patients were randomly put into two groups of case [M=8, F=10, Mean age=27] and control [M=8, F=10, Mean age=29]. Case group participated in eight week aerobic exercise plan, while control group had no plan of exercise. Pulmonary function tests were done before and after the course of exercise. There were significant changes in FEV1, FVC, PEF, FEF[25-75%], MVV, RF and 6MWT between asthmatic patients of the two groups [P